Tolerance isnt just filtration. That's one part certainly.
Several drugs are broken down by specific enzymes and therefore your tolerance for the drug will depend on whether you make the enzyme and how much. The canonic example is codeine.
Codeine doesnt do anything on its own. Your liver makes an enzyme that turns codeine into morphine, and this is what has an effect.
So, if you are one of the 6% of caucasions that do not have the gene for that enzyme, codeine will do nothing for you. Oops.
If you are one of (I dont know the percentage) who OVERexpress the enzyme, you will convert the codeine into morphine very fast--giving you a higher dose for shorter duration.
It's possible that exposure to certain toxins will create a positive feedback system where you overexpress the enzymes to degrade them. This probably depends on the specific mechanisms of the toxin.
Also, toxins that bind permanently and build up are probably not ones you want to try to build immunities to...
![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
no subject
Tolerance isnt just filtration. That's one part certainly.
Several drugs are broken down by specific enzymes and therefore your tolerance for the drug will depend on whether you make the enzyme and how much. The canonic example is codeine.
Codeine doesnt do anything on its own. Your liver makes an enzyme that turns codeine into morphine, and this is what has an effect.
So, if you are one of the 6% of caucasions that do not have the gene for that enzyme, codeine will do nothing for you. Oops.
If you are one of (I dont know the percentage) who OVERexpress the enzyme, you will convert the codeine into morphine very fast--giving you a higher dose for shorter duration.
It's possible that exposure to certain toxins will create a positive feedback system where you overexpress the enzymes to degrade them. This probably depends on the specific mechanisms of the toxin.
Also, toxins that bind permanently and build up are probably not ones you want to try to build immunities to...