I don't have a hugely strongly dominant hand, but yeah, there are lots of things that are difficult to do one-handed. Particularly things you can't reach with your teeth to help out, like zippers, shoelaces, and hair ties. I've never had one hand out of commission for long, so I don't know how I'd deal.

The feet though -- gawd, I would recommend to anyone considering this surgery: think hard about whether you want both feet unusable at once. I'm VERY lucky I heal fast and am quickly moving out of the most troublesome time.