I think that depends on the definition of "extreme." Is that "extreme considering risk" or "extreme disregarding risk"?

I took fairly massive doses of tylenol, advil, aleve etc. while in high school because my migraines hadn't been diagnosed yet. I fear I have done myself unnecessary liver damage, because there were better alternatives, though I didn't know about yet. However, if there were no alternatives, and the doctor explained that I'd be doing the damage, I'd have the weigh the damage versus the pain.